3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles
CM Uyehara, E Apostolou - Cell reports, 2023 - cell.com
The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …
regulatory sequences, called enhancers, which regulate target genes over variable genomic …
A phase separation model for transcriptional control
Phase-separated multi-molecular assemblies provide a general regulatory mechanism to
compartmentalize biochemical reactions within cells. We propose that a phase separation …
compartmentalize biochemical reactions within cells. We propose that a phase separation …
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive
therapeutic efficacy against leukemias and lymphomas. However, they have not been as …
therapeutic efficacy against leukemias and lymphomas. However, they have not been as …
Sequence determinants of human gene regulatory elements
DNA can determine where and when genes are expressed, but the full set of sequence
determinants that control gene expression is unknown. Here, we measured the …
determinants that control gene expression is unknown. Here, we measured the …
Super-enhancers in the control of cell identity and disease
D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint-André… - Cell, 2013 - cell.com
Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …
genes that define cell identity. Improved understanding of the roles that super-enhancers …
[HTML][HTML] Master transcription factors and mediator establish super-enhancers at key cell identity genes
Summary Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …
The transcription factor NFAT promotes exhaustion of activated CD8+ T cells
During persistent antigen stimulation, CD8+ T cells show a gradual decrease in effector
function, referred to as exhaustion, which impairs responses in the setting of tumors and …
function, referred to as exhaustion, which impairs responses in the setting of tumors and …
Selective inhibition of tumor oncogenes by disruption of super-enhancers
Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why
inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells …
inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells …
The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2
DA Chistiakov, VA Myasoedova, VV Revin… - Immunobiology, 2018 - Elsevier
The mononuclear phagocytes control the body homeostasis through the involvement in
resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental …
resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental …
[HTML][HTML] Direct observation of a condensate effect on super-enhancer controlled gene bursting
Enhancers are distal DNA elements believed to loop and contact promoters to control gene
expression. Recently, we found diffraction-sized transcriptional condensates at genes …
expression. Recently, we found diffraction-sized transcriptional condensates at genes …