Inclusion body myositis (IBM) is unique across the spectrum of idiopathic inflammatory
myopathies (IIM) due to its distinct clinical presentation and refractoriness to current …

The myotendinous junction (MTJ) is a specialized domain of the multinucleated myofibre
that is faced with the challenge of maintaining robust cell–matrix contact with the tendon …

Cellular senescence is a driver of many age-related pathologies. There is an active search
for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by …

Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disorder caused by
mutations in the Dystrophin gene and for which there is currently no cure. To bridge the gap …

Gene knockout (KO) experiments are a proven, powerful approach for studying gene
function. However, systematic KO experiments targeting a large number of genes are …

The routine need for myonuclear turnover in skeletal muscle, together with more sporadic
demands for hypertrophy and repair, are performed by resident muscle stem cells called …

High-throughput gene expression profiling measures individual gene expression across
conditions. However, genes are regulated in complex networks, not as individual entities …

Chrysophrys auratus (Australasian snapper) is one of the largest and most valuable finfish
from capture fisheries in New Zealand, yet no cell lines from this species are reported in the …

Skeletal muscle (SkM) comprises slow and fast-twitch fibers, which differ in molecular
composition, function, and systemic energy consumption. In addition, muscular dystrophies …

Skeletal muscle has long been established as a highly multifunctional organ, playing a vital
role in locomotion, whole-body metabolic and energy homeostasis, and thermoregulation …