Identification of RNA structures and their roles in RNA functions

X Cao, Y Zhang, Y Ding, Y Wan - Nature Reviews Molecular Cell …, 2024 - nature.com
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …

Revisiting the mesenchymal “stem vs. stromal” cell dichotomy and its implications for development of improved potency metrics

DG Phinney, R Hwa Lee, SV Boregowda - Stem Cells, 2023 - academic.oup.com
Mesenchymal stem/stromal cell (MSC)-based therapies have been evaluated in over 1500
human clinical trials for a diverse array of disease indication, but outcomes remain …

Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection

W Kamel, M Noerenberg, B Cerikan, H Chen… - Molecular cell, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to …

Glutamyl-prolyl-tRNA synthetase regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis

J Wu, KCV Subbaiah, LH Xie, F Jiang, ES Khor… - Circulation …, 2020 - Am Heart Assoc
Rationale: Increased protein synthesis of profibrotic genes is a common feature in cardiac
fibrosis and heart failure. Despite this observation, critical factors and molecular …

A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon

D Khan, F Terenzi, GQ Liu, PK Ghosh, F Ye… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer …

Unconventional RNA‐binding proteins step into the virus–host battlefront

M Garcia‐Moreno, AI Järvelin… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
The crucial participation of cellular RNA‐binding proteins (RBPs) in virtually all steps of virus
infection has been known for decades. However, most of the studies characterizing this …

Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture

JI Perez-Perri, M Noerenberg, W Kamel, CE Lenz… - Nature protocols, 2021 - nature.com
Interactions between RNA-binding proteins (RBPs) and RNAs are critical to cell biology.
However, methods to comprehensively and quantitatively assess these interactions within …

Mechanistic target of rapamycin in regulating macrophage function in inflammatory cardiovascular diseases

MSC Mangione, J Wen, DJ Cao - Journal of molecular and cellular …, 2024 - Elsevier
The mechanistic target of rapamycin (mTOR) is evolutionarily conserved from yeast to
humans and is one of the most fundamental pathways of living organisms. Since its …

[HTML][HTML] Tumor associated macrophages transfer ceruloplasmin mRNA to fibrosarcoma cells and protect them from ferroptosis

A Schwantes, A Wickert, S Becker, PC Baer, A Weigert… - Redox biology, 2024 - Elsevier
Solid tumors are characterized by hypoxic areas, which are prone for macrophage
infiltration. Once infiltrated, macrophages polarize to tumor associated macrophages (TAM) …

Baicalin Induces a Potent Innate Immune Response to Inhibit Respiratory Syncytial Virus Replication via Regulating Viral Non-Structural 1 and Matrix RNA

S Qin, X Huang, S Qu - Frontiers in Immunology, 2022 - frontiersin.org
Respiratory syncytial virus (RSV) infection is the most frequent cause of hospitalization in
pediatric patients. Current systemic treatment and vaccines are not curative and re-infection …