Cancer-associated fibroblasts in the single-cell era
Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …
[HTML][HTML] Fibroblasts in cancer: Unity in heterogeneity
Y Chhabra, AT Weeraratna - Cell, 2023 - cell.com
Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …
Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts,
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …
[HTML][HTML] Ovarian cancer mutational processes drive site-specific immune evasion
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability,,–
patterned by distinct mutational processes,, tumour heterogeneity,–and intraperitoneal …
patterned by distinct mutational processes,, tumour heterogeneity,–and intraperitoneal …
Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy
Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we
characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer …
characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer …
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression
Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-
characterized pathological stages of initiation and progression. However, high-resolution …
characterized pathological stages of initiation and progression. However, high-resolution …
Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer
X Zheng, X Wang, X Cheng, Z Liu, Y Yin, X Li, Z Huang… - Nature Cancer, 2023 - nature.com
Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with
widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC …
widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC …
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
Recent studies have identified a unique cancer-associated fibroblast (CAF) population
termed antigen-presenting CAFs (apCAFs), characterized by the expression of major …
termed antigen-presenting CAFs (apCAFs), characterized by the expression of major …
[HTML][HTML] Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …
oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic …
Single-cell RNA sequencing reveals the tissue architecture in human high-grade serous ovarian cancer
J Xu, Y Fang, K Chen, S Li, S Tang, Y Ren, Y Cen… - Clinical Cancer …, 2022 - AACR
Purpose: The heterogeneity of high-grade serous ovarian cancer (HGSOC) is not well
studied, which severely hinders clinical treatment of HGSOC. Thus, it is necessary to …
studied, which severely hinders clinical treatment of HGSOC. Thus, it is necessary to …