Mitochondria contain two aqueous compartments: the matrix and the intermembrane space.
Whereas many of the biologic functions of the matrix were well characterized in the past, it …

Mitochondria are ubiquitous organelles that are intimately involved in many cellular
processes, but whose principal task is to provide the energy necessary for normal cell …

A classical approach, protein separation by two-dimensional blue native/sodium dodecyl
sulfate-polyacrylamide gel electrophoresis, was combined with tandem mass spectrometry …

The functionality of the mitochondrion is primarily determined by nuclear encoded proteins.
The mitochondrial functional requirements of different tissues vary from a significant …

Abstract Objective Superoxide dismutase 2 (SOD2) is down‐regulated in osteoarthritis (OA).
This study was undertaken to investigate the functional effects of this down‐regulation in the …

Endosymbiosis and organellogenesis are virtually unknown among prokaryotes. The single
presumed example is the endosymbiogenetic origin of mitochondria, which is hidden behind …

The role of plant mitochondrial outer membrane proteins in the process of preprotein import
was investigated, as some of the principal components characterized in yeast have been …

In contrast to other organisms, gram-negative bacteria have evolved numerous systems for
protein export. Eight types are known that mediate export across or insertion into the …

Mitochondrial protein import is a complex multistep process from synthesis of proteins in the
cytosol, recognition by receptors on the organelle surface, to translocation across one or …

The enzyme fumarase is a conserved protein in all organisms with regard to its sequence,
structure and function. This enzyme participates in the tricarboxylic acid cycle in …