Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …

The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting
proteolytic systems. They play critical roles in cell survival under normal conditions and …

Abstract In mammals, the Keap1-Nrf2-ARE pathway (henceforth,“the Nrf2 pathway”) and
autophagy are major intracellular defence systems that combat oxidative damage and …

ABSTRACT SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold
protein involved in diverse cellular processes. Its functions are tightly regulated through an …

p62 is a stress‐inducible protein able to change among binding partners, cellular
localizations and form liquid droplet structures in a context‐dependent manner. This protein …

Mounting evidence suggests that autophagy is a more selective process than originally
anticipated. The discovery and characterization of autophagic adapters, like p62 and NBR1 …

The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic
degradation of ubiquitinated targets, is up-regulated by various stressors. Induction of the …

Selective macroautophagy (autophagy) of ubiquitinated protein is implicated as a
compensatory mechanism of the ubiquitin-proteasome system. p62/SQSTM1 is a key …

Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …