Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

Recent structural characterizations of classical and non‐classical major histocompatibility
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …

Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …

The mechanisms of HLA-DM-catalyzed peptide exchange remain uncertain. Here we found
that all stages of the interaction of HLA-DM with HLA-DR were dependent on the occupancy …

HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …

Abstract Background The duck (Anas platyrhynchos) is one of the principal natural hosts of
influenza A virus (IAV), harbors almost all subtypes of IAVs and resists to many IAVs which …

Abstract MHC class I (MHC-I) proteins of the adaptive immune system require antigenic
peptides for maintenance of mature conformation and immune function via specific …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs),
which are proteins that cause post-synaptic blockade and paralysis in snakebite …

Abstract HLA-DM (DM) is a nonclassical MHC class II (MHC II) protein that acts as a peptide
editor to mediate the exchange of peptides loaded onto MHC II during Ag presentation …