Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

Iron, an essential nutrient, is required for many diverse biological processes. The absence of
a defined pathway to excrete excess iron makes it essential for the body to regulate the …

Iron, insoluble as free Fe 3+ and toxic as free Fe 2+, is distributed through the body as Fe 3+
bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin …

Iron is a crucial factor for life. However, it also has the potential to cause the formation of
noxious free radicals. These double-edged sword characteristics demand a tight regulation …

Anemia is prevalent in patients with chronic kidney disease (CKD) and is associated with
lower quality of life and higher risk of adverse outcomes, including cardiovascular disease …

BACKGROUND: Not long after the Big Bang, iron began to play a central role in the
Universe and soon became mired in the tangle of biochemistry that is the prima essentia of …

We have assembled a nonredundant set of 144 protein–protein complexes that have high‐
resolution structures available for both the complexes and their unbound components, and …

Hemochromatosis is caused by mutations in HFE, a protein that competes with transferrin
(TF) for binding to transferrin receptor 1 (TFR1). We developed mutant mouse strains to gain …

Transition metal ions are essential nutrients to all forms of life. Iron, copper, zinc,
manganese, cobalt and nickel all have unique chemical and physical properties that make …