Several chemicals, including environmental toxicants and clinically useful drugs, cause
severe cellular damage to different organs of our body through metabolic activation to highly …

Myeloid cells are a significant proportion of leukocytes within tissues, comprising
granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various …

Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires
resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis throughout
life, and understanding how these cells function has important implications for …

Macrophages are a heterogeneous group of cells that are capable of carrying out distinct
functions in different tissues, as well as in different locations within a given tissue. Some of …

Infection by bacteria, viruses, and parasites may lead to fetal death, organ injury, or limited
sequelae depending on the pathogen. Here, we consider the role of infection during …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …