Capturing the environment of the Clostridioides difficile infection cycle

MK Schnizlein, VB Young - Nature Reviews Gastroenterology & …, 2022 - nature.com
Clostridioides difficile (formerly Clostridium difficile) infection is a substantial health and
economic burden worldwide. Great strides have been made over the past several years in …

Efficacy, safety, and cost-effectiveness of bezlotoxumab in preventing recurrent Clostridioides difficile infection: systematic review and meta-analysis

MFH Mohamed, C Ward, A Beran… - Journal of Clinical …, 2024 - journals.lww.com
Methods: We performed a systematic review and meta-analysis to pool the rate of rCDI in
patients receiving BEZ and explore its efficacy and safety in preventing rCDI compared with …

A Phase 2 Extension Study Evaluating the Immunogenicity, Safety, and Tolerability of 3 or 4 Doses of a Clostridioides difficile Vaccine in Healthy US Adults Aged 65 …

S Remich, N Kitchin, J Peterson, P Li… - The Journal of …, 2024 - academic.oup.com
Background This phase 2 extension explored the long-term antibody persistence of an
investigational Clostridioides difficile vaccine and the safety, tolerability, and immunogenicity …

[HTML][HTML] Hyperimmune globulins for the management of infectious diseases

I Pati, M Cruciani, F Candura, MS Massari, V Piccinini… - Viruses, 2023 - mdpi.com
This review is focused on the use of hyperimmune globulin therapy to treat some infectious
diseases of viral or bacterial origin. Despite the introduction of antibiotics and vaccines …

Add-on interventions for the prevention of recurrent Clostridioides Difficile infection: A systematic review and network meta-analysis

P Paschos, K Ioakim, K Malandris, A Koukoufiki… - Anaerobe, 2021 - Elsevier
Objectives We aimed to assess the comparative efficacy and safety of adjunctive
interventions for the prevention of Clostridioides difficile recurrence. Methods We searched …

Pregnancy and neonatal outcomes in women receiving calcineurin inhibitors: A systematic review and meta‐analysis

S Akiyama, S Hamdeh, N Murakami… - British Journal of …, 2022 - Wiley Online Library
Aims: Calcineurin inhibitors (CNIs) are often used for solid organ transplantation recipients
or patients with immune‐mediated diseases. This systematic review and meta‐analysis aims …

Prevalence and clinical features of patients with autoimmune pancreatitis and inflammatory bowel disease: A systematic review and meta‐analysis

S Fukuda, S Akiyama, A Tarakji… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Aim Autoimmune pancreatitis (AIP) and inflammatory bowel
disease (IBD) are categorized into immune‐mediated inflammatory disorders (IMIDs). While …

Therapeutic Strategies to Combat Increasing Rates of Multidrug Resistant Pathogens

A Vitiello, G Rezza, A Silenzi, A Salzano, M Alise… - Pharmaceutical …, 2024 - Springer
The emergence of antimicrobic-resistant infectious pathogens and the consequent rising in
the incidence and prevalence of demises caused by or associated to infections which are …

The feasibility, safety, and long-term outcomes of endoscopic submucosal dissection for colorectal neoplasia in patients with inflammatory bowel disease: A systematic …

S Akiyama, S Hamdeh, T Sakamoto… - Journal of Clinical …, 2023 - journals.lww.com
Background: Evidence regarding the utility of endoscopic submucosal dissection (ESD) for
neoplasia in patients with inflammatory bowel disease (IBD) is limited. This meta-analysis …

Renal Impairment, C. difficile Recurrence, and the Differential Effect of Bezlotoxumab: A Post Hoc Analysis of Pooled Data From 2 Randomized Clinical Trials

Y Golan, HL DuPont, F Aldomiro… - Open Forum …, 2020 - academic.oup.com
Background Renal impairment is not a consistently cited risk factor for recurrent
Clostridioides difficile infection (rCDI). We examined the association between renal …