Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance

J Rojas, I Buckner, V Kumar - Drug development and industrial …, 2012 - Taylor & Francis
It is necessary to have excipients with excellent functional properties to compensate for the
poor mechanical properties and low aqueous solubility of the emerging active ingredients …

Application of multivariate methods to compression behavior evaluation of directly compressible materials

RV Haware, I Tho, A Bauer-Brandl - European Journal of Pharmaceutics …, 2009 - Elsevier
The present study is an approach to describe and predict compaction and tablet properties
by a combination of a set of commonly used mathematical descriptors and multivariate …

The effect of compression and decompression speed on the mechanical strength of compacts

CE Ruegger, M Çelick - Pharmaceutical development and …, 2000 - Taylor & Francis
The purpose of this work was to investigate the effect of punch speed on the compaction
properties of pharmaceutical powders; in particular, to separate out differences between the …

Evaluation of a rapid approximation method for the elastic recovery of tablets

RV Haware, I Tho, A Bauer-Brandl - Powder Technology, 2010 - Elsevier
The present work evaluates the usefulness of “in die” elastic recovery descriptors as an
indicator of tabletability. Tablet elastic recovery (“in die” and “out-of-die”) with respect to …

Study of the compaction behaviour and compressibility of binary mixtures of some pharmaceutical excipients during direct compression

P Kása, J Bajdik, Z Zsigmond, K Pintye-Hódi - Chemical Engineering and …, 2009 - Elsevier
Tablets produced in the pharmaceutical industry consist of more than one component. The
densification behaviour, the compaction properties of a formulation are strongly influenced …

Negative porosity issue in the Heckel analysis: A possible solution

D Patel, VD Patel, R Sedlock, RV Haware - International Journal of …, 2022 - Elsevier
A parameterization of compaction simulator generated dynamic compression profile with a
few grams of powder provides important information about the material deformation and …

[PDF][PDF] Brief Overview on Compaction and Compression of Bilayer Technology

SA Tadavi, MR Patel - Journal of pharmacy research, 2011 - Citeseer
Several pharmaceutical companies are currently developing bi-layer tablets for a variety of
reasons for patent extension, increasing therapeutic activities, to modify the better drug …

The past, present, and future of tableting technology

M Çelik - Drug development and industrial pharmacy, 1996 - Taylor & Francis
The evolution of tableting technology was briefly reviewed and the predictions and
suggestions for the future of this field were made. The factors that would be primarily …

A new theoretical model to characterize the densification behavior of tableting materials

KM Picker - European Journal of Pharmaceutics and …, 2000 - Elsevier
The purpose of the study was to develop a new three-dimensional model using force, time
and displacement to characterize the densification behavior of tableting materials …

The influence of varying precompaction and main compaction profile parameters on the mechanical strength of compacts

CE Ruegger, M Çelik - Pharmaceutical development and …, 2000 - Taylor & Francis
The purpose of this work was to investigate how altering the method of force application
could be beneficial to tablet production in order to increase tablet strength and eliminate or …