Medial vascular calcification has emerged as a putative key factor contributing to the
excessive cardiovascular mortality of patients with chronic kidney disease (CKD) …

Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and
in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that …

Medial vascular calcification, associated with enhanced mortality in chronic kidney disease
(CKD), is fostered by osteo-/chondrogenic transdifferentiation of vascular smooth muscle …

Platelets store and release CXCL12 (SDF-1), which governs differentiation of hematopoietic
progenitors into either endothelial or macrophage-foam cells. CXCL12 ligates CXCR4 and …

Activation of the PI3K pathway is central to a variety of physiological and pathological
processes. In these contexts, AKT is classically considered the de facto mediator of PI3K …

The mineralocorticoid receptor (MR) is a member of the nuclear receptor steroid-binding
family. The classical MR ligand aldosterone controls electrolyte and fluid homeostasis after …

Nuclear factor of activated T cells 5 (NFAT5), a Rel/nuclear factor‐(NF‐) κB family member,
is the only known gene regulator of the mammalian adaptive response to osmotic stress …

Ménière's disease, a multifactorial disorder of the inner ear, is characterized by severe
vertigo episodes and hearing loss. Although the role of immune responses in Ménière's …

This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

Objective—Restenosis after percutaneous coronary intervention remains to be a serious
medical problem. Although mineralocorticoid receptor (MR) has been implicated as a …