Spinal muscular atrophy is typically characterized as a motor neuron disease. Untreated
patients with the most severe form, spinal muscular atrophy type 1, die early with infantile …

Spinal muscular atrophy (SMA) is the most common genetically inherited neurodegenerative
disease resulting in infant mortality. SMA is caused by genetic deletion or mutation in the …

Objective Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder leading to
paralysis and subsequent death in young children. Initially considered a motor neuron …

The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of
transcription factors. FOXO proteins were originally identified as regulators of insulin-related …

Spinal muscular atrophy (SMA) is an autosomal recessive genetic disorder leading to
paralysis, muscle atrophy, and death. Significant advances in antisense oligonucleotide …

Skeletal muscle atrophy is a common side effect of most human diseases. Muscle loss is not
only detrimental for the quality of life but it also dramatically impairs physiological processes …

Spinal muscular atrophy (SMA), the main genetic cause of infant death, is a
neurodegenerative disease characterized by the selective loss of motor neurons in the …

Spinal muscular atrophy (SMA) has long been solely considered a neurodegenerative
disorder. However, recent work has highlighted defects in many other cell types that could …

Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease of variable
clinical severity that is caused by mutations in the survival motor neuron 1 (SMN1) gene …

The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-
BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide …