Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store …

Perturbation of intracellular ion homeostasis is a major cellular stress signal for activation of
NLRP3 inflammasome signaling that results in caspase-1–mediated production of IL-1β and …

Background and purpose Pyrazole derivatives have recently been suggested as selective
blockers of transient receptor potential cation (TRPC) channels but their ability to distinguish …

Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …

Plasma-membrane-localized Orai1 ion channel subunits interacting with ER-localized
STIM1 molecules comprise the major subunit composition responsible for calcium release …

Abstract Ca2+ release-activated Ca2+ (CRAC) channels, indispensable for the immune
system and various other human body functions, consist of two transmembrane (TM) …

Background: STIM1 and Orai1, reconstituting a main cellular Ca 2+ entry pathway, interact
via their cytosolic strands. Results: The extended transmembrane Orai1 N-terminal (ETON) …

The ER-resident regulatory protein STIM1 triggers store-operated Ca2+ entry by direct
interaction with the plasma membrane Ca2+ channel ORAI1. The mechanism of channel …

NFAT-dependent gene expression is essential for the development and function of the
nervous, immune, and cardiovascular systems and kidney, bone, and skeletal muscle [1] …