Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic
nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of ionizable lipids …

In recent years, dendrimer-based vesicles, known as dendrimersomes, have garnered
significant attention as highly promising alternatives to lipid vesicles in a variety of …

This perspective begins with an overview of the major impact that the dendron, dendrimer,
and dendritic state (DDDS) discovery has made on traditional polymer science. The entire …

One-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimers
(IAJDs) were discovered in our laboratories in 2021 to represent a new class of synthetic …

Constitutional isomerism has been previously demonstrated by one of our laboratories to
represent a powerful design strategy for the elaboration of complex functional self …

Ionizable lipids largely determine the biocompatibility of lipid nanoparticles (LNPs) and the
efficacy for mRNA delivery. Rational design and combinatorial synthesis have led to the …

This Perspective is dedicated to the 25th Anniversary of Biomacromolecules. It provides a
personal view on the developing field of the polymer and biology interface over the 25 years …

In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great
interest in both immunotherapy and non-immunogenic applications. This surge in interest …

Spherical supramolecular dendrimers including helical, self-organize soft Frank–Kasper,
other cubic such as body-centered cubic, and quasicrystal periodic and quasiperiodic …

Four-component lipid nanoparticles (LNPs) and viral vectors are key for mRNA vaccine and
therapeutics delivery. LNPs contain ionizable lipids, phospholipids, cholesterol, and …