Immunotherapy holds the potential to induce durable responses, but only a minority of
patients currently respond. The etiologies of primary and secondary resistance to …

Cancerous lesions promote tumor growth, motility, invasion, and angiogenesis via
oncogene-driven immunosuppressive leukocyte infiltrates, mainly myeloid-derived …

Background Cytotoxic chemotherapeutics form the cornerstone of systemic treatment of
many cancers. Patients are dosed at maximum tolerated dose (MTD), which is carefully …

Background: Some cancer patients are immuno-compromised, and it has been long felt that
immune-intervention is not compatible with standard chemotherapies. However, increasing …

Historically, the 4Rs and then the 5Rs of radiobiology explained the effect of radiation
therapy (RT) fractionation on the treatment efficacy. These 5Rs are: Repair, Redistribution …

6,630,575 B2 10/2003 Coyle et al. 6,635,750 B1 10/2003 Coyle et al. 6,803, 192 B1 10,
2004 Chen 6,808,710 B1 10, 2004 Wood et al. 6,965,018 B2 11/2005 Mikesell et al …

There are few effective treatment options available for patients with advanced melanoma. An
oncolytic herpes simplex virus type 1 encoding granulocyte macrophage colony-stimulating …

This study investigated the effects of the exopolysaccharide from Lactiplantibacillus
plantarum JLAU103 (EPS103) on the intestinal immune response, oxidative stress, intestinal …

Abstract CD4+ CD25+ Foxp3+ regulatory T (Treg) cells have been shown to play important
roles in mediating cancer development. Although cyclophosphamide (CY) has shown …

5,175,099 A 12, 1992 Wills 5, 190,929 A 3, 1993 Borch(57) ABSTRACT-5,204.243 A 4, 1993
Paoletti Methods of treating cancer and infectious diseases utilizing a 5,223,409 A 6, 1993 …