The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective

G Williamson, CD Kay, A Crozier - Comprehensive Reviews in …, 2018 - Wiley Online Library
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …

Flavanones: Citrus phytochemical with health‐promoting properties

D Barreca, G Gattuso, E Bellocco, A Calderaro… - …, 2017 - Wiley Online Library
Citrus fruit and juices represent one of the main sources of compounds with a high potential
for health promoting properties. Among these compounds, flavanones (such as hesperetin …

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

G Williamson, MN Clifford - Biochemical pharmacology, 2017 - Elsevier
Abstract (Poly) phenols are a large group of compounds, found in food, beverages, dietary
supplements and herbal medicines. Owing to interest in their biological activities, absorption …

Evaluation of blood–brain barrier permeability of polyphenols, anthocyanins, and their metabolites

R Shimazu, M Anada, A Miyaguchi… - Journal of Agricultural …, 2021 - ACS Publications
Anthocyanins (ACs) are able to protect neurons against β-amyloid-induced neurotoxicity. In
this study, we evaluated blood–brain barrier (BBB) permeability of these compounds using a …

Anthocyanins and flavanones are more bioavailable than previously perceived: A review of recent evidence

CD Kay, G Pereira-Caro, IA Ludwig… - Annual Review of …, 2017 - annualreviews.org
This review considers recent investigations on the bioavailability of anthocyanins and
flavanones. Both flavonoids are significant dietary components and are considered to be …

Beneficial effects of citrus flavanones naringin and naringenin and their food sources on lipid metabolism: An update on bioavailability, pharmacokinetics, and …

Y Yang, M Trevethan, S Wang, L Zhao - The Journal of nutritional …, 2022 - Elsevier
Naringin and naringin's aglycone naringenin belong to a subclass of flavonoids called
flavanones. While many studies of pure naringenin and naringin and their food sources …

[HTML][HTML] The intestinal fate of citrus flavanones and their effects on gastrointestinal health

Y Stevens, EV Rymenant, C Grootaert, JV Camp… - Nutrients, 2019 - mdpi.com
Citrus flavanones, with hesperidin and naringin as the most abundant representatives, have
various beneficial effects, including anti-oxidative and anti-inflammatory activities. Evidence …

[HTML][HTML] Potential roles of gut microbes in biotransformation of natural products: An overview

Y Zhao, X Zhong, J Yan, C Sun, X Zhao… - Frontiers in …, 2022 - frontiersin.org
Natural products have been extensively applied in clinical practice, characterized by multi-
component and multi-target, many pharmacodynamic substances, complex action …

[HTML][HTML] Hesperidin effects on gut microbiota and gut-associated lymphoid tissue in healthy rats

S Estruel-Amades, M Massot-Cladera, FJ Pérez-Cano… - Nutrients, 2019 - mdpi.com
Hesperidin, found in citrus fruits, has shown a wide range of biological properties.
Nonetheless, a more in-depth investigation is required on the effects on the immune system …

Citrus flavonoids and the intestinal barrier: Interactions and effects

M Wang, H Zhao, X Wen, CT Ho… - … Reviews in Food Science …, 2021 - Wiley Online Library
The intestinal barrier plays a central role in sustaining gut homeostasis and, when
dysfunctional, may contribute to diseases. Dietary flavonoids derived from Citrus genus …