Mesenchymal stem cell therapies in brain disease

LS Sherman, MP Romagano, SF Williams… - Seminars in cell & …, 2019 - Elsevier
As treatments for diseases throughout the body progress, treatment for many brain diseases
has been at a standstill due to difficulties in drug delivery. While new drugs are being …

The power of zebrafish in personalised medicine

S Baxendale, F van Eeden, R Wilkinson - Personalised Medicine: Lessons …, 2017 - Springer
The goal of personalised medicine is to develop tailor-made therapies for patients in whom
currently available therapeutics fail. This approach requires correlating individual patient …

Autologous bone marrow-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients

WA El-Kheir, H Gabr, MR Awad… - Cell …, 2014 - journals.sagepub.com
Spinal cord injuries (SCI) cause sensory loss and motor paralysis. They are normally treated
with physical therapy, but most patients fail to recover due to limited neural regeneration …

Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

JL Munoz, V Rodriguez-Cruz, SJ Greco… - Cell death & …, 2014 - nature.com
Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor
prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide …

Optimized 3D culture of hepatic cells for liver organoid metabolic assays

CM Gamboa, Y Wang, H Xu, K Kalemba… - Cells, 2021 - mdpi.com
The liver is among the principal organs for glucose homeostasis and metabolism. Studies of
liver metabolism are limited by the inability to expand primary hepatocytes in vitro while …

Mesenchymal stromal/stem cells in drug therapy: New perspective

LS Sherman, M Shaker, V Mariotti, P Rameshwar - Cytotherapy, 2017 - Elsevier
Mesenchymal stromal/stem cells (MSC) have emerged as a class of cells suitable for cellular
delivery of nanoparticles, drugs and micro-RNA cargo for targeted treatments such as tumor …

A discussion on adult mesenchymal stem cells for drug delivery: pros and cons

LS Sherman, A Condé-Green, OA Sandiford… - Therapeutic …, 2015 - Taylor & Francis
Mesenchymal stem cells (MSCs) are emerging as candidates for drug delivery to treat
numerous diseases. Their ease of isolation, expansion and reduced ethical concern …

Intrathecal transplantation of autologous adherent bone marrow cells induces functional neurological recovery in a canine model of spinal cord injury

H Gabr, WA El-Kheir, HAMA Farghali… - Cell …, 2015 - journals.sagepub.com
Spinal cord injury (SCI) results in demyelination of surviving axons, loss of oligodendrocytes,
and impairment of motor and sensory functions. We have developed a clinical strategy of …

Minimally manipulated autologous adherent bone marrow cells (ABMCs): a promising cell therapy of spinal cord injury

K Misra, HE Sabaawy - Neural Regeneration Research, 2015 - journals.lww.com
Spinal cord injury (SCI) is a devastating ailment that results in drastic life style alterations for
the patients and their family members (McDonald and Sadowsky, 2002). Damage post injury …

自体骨髓衍生细胞: 治疗脊髓损伤的细胞疗法

K Misra, HE Sabaawy - 中国神经再生研究(英文版), 2015 - sjzsyj.com.cn
脊髓损伤是一种破坏性疾病, 会给病患及病人家属的生活方式造成剧烈改变,
长期以来一直被认为是不可逆的, 但细胞疗法的最新研究进展给脊髓损伤带来了希望 …