Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …

Currently available evidence strongly supports the position that the initiating event in
Alzheimer's disease (AD) is related to abnormal processing of β-amyloid (Aβ) peptide …

Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

Objective To examine interactions of apolipoprotein E (APOE) genotype with age and with in
vivo measures of preclinical Alzheimer disease (AD) in cognitively normal aging. Methods …

Identifying high-risk populations is an important component of disease prevention strategies.
One approach for identifying at-risk populations for Alzheimer's disease (AD) is examining …

Background Imaging with amyloid-β PET can potentially aid the early and accurate
diagnosis of Alzheimer's disease. Florbetaben (18 F) is a promising 18 F-labelled amyloid-β …

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. At the
time of clinical manifestation of dementia, significant irreversible brain damage is already …

In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years …

Some patients with early-onset Alzheimer's disease (AD) present with a distinct phenotype.
Typically, the first and most salient characteristic of AD is episodic memory impairment. A …