Lipidomic profiling of human serum enables detection of pancreatic cancer

D Wolrab, R Jirásko, E Cífková, M Höring, D Mei… - Nature …, 2022 - nature.com
Pancreatic cancer has the worst prognosis among all cancers. Cancer screening of body
fluids may improve the survival time prognosis of patients, who are often diagnosed too late …

Clinical trials targeting the stroma in pancreatic cancer: a systematic review and meta-analysis

MG van Mackelenbergh, CI Stroes, R Spijker… - Cancers, 2019 - mdpi.com
The tumor microenvironment plays an important role in the initiation and progression of
pancreatic adenocarcinoma (PDAC). In this systematic review, we provide an overview of …

Non-invasive biomarkers for earlier detection of pancreatic cancer—A comprehensive review

G Brezgyte, V Shah, D Jach, T Crnogorac-Jurcevic - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC), which represents
approximately 90% of all pancreatic cancers, is an extremely aggressive and lethal disease …

Comprehensive characterization of complex glycosphingolipids in human pancreatic cancer tissues

K Hořejší, C Jin, Z Vaňková, R Jirásko… - Journal of Biological …, 2023 - ASBMB
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-
related deaths worldwide, accounting for 90% of primary pancreatic tumors with an average …

Elevated expression of exosomal microRNA‑21 as a potential biomarker for the early diagnosis of pancreatic cancer using a tethered cationic lipoplex nanoparticle …

X Pu, G Ding, M Wu, S Zhou, S Jia… - Oncology …, 2020 - spandidos-publications.com
Pancreatic cancer (PC) has a poor prognosis due to the lack of effective molecular
biomarkers for early diagnosis. Recent studies have investigated the use of exosomal …

Clinical perspective on proteomic and glycomic biomarkers for diagnosis, prognosis, and prediction of pancreatic cancer

RG Hanna-Sawires, JH Schiphuis, M Wuhrer… - International Journal of …, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is known as a highly aggressive malignant
disease. Prognosis for patients is notoriously poor, despite improvements in surgical …

[HTML][HTML] Recent advances in understanding pancreatic cancer

MC Stott, L Oldfield, J Hale, E Costello… - Faculty …, 2022 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer and a leading cause of
cancer deaths worldwide. Over 90% of patients die within 1 year of diagnosis. Deaths from …

[HTML][HTML] Protein biomarkers for diagnosis of breast cancer

EEJ Iweala, DN Amuji, FC Nnaji - Scientific African, 2024 - Elsevier
Breast cancer remains a major global health challenge, demanding better diagnostic tools.
Traditional methods like mammography have limitations, highlighting the need for specific …

Blood-based extracellular matrix biomarkers as predictors of survival in patients with metastatic pancreatic ductal adenocarcinoma receiving pegvorhyaluronidase alfa

S Wang, CL Bager, MA Karsdal, D Chondros… - Journal of Translational …, 2021 - Springer
Background Extensive extracellular matrix (ECM) remodeling is a hallmark of metastatic
pancreatic ductal adenocarcinoma (mPDA). We investigated fragments of collagen types III …

Mucin expression and splicing determine novel subtypes and patient mortality in pancreatic ductal adenocarcinoma

CM Thompson, A Cannon, S West, D Ghersi, P Atri… - Clinical Cancer …, 2021 - AACR
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy
demonstrating aberrant and progressive expression of mucins. The contribution of individual …