The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19

C Perricone, P Triggianese, E Bartoloni, G Cafaro… - Journal of …, 2020 - Elsevier
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an …

[HTML][HTML] Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies

GM Nitulescu, H Paunescu… - International …, 2020 - spandidos-publications.com
The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS‑
CoV‑2) focused many researchers attention to find treatments that can suppress …

[HTML][HTML] Targeting IL-1β as an immunopreventive and therapeutic modality for K-ras–mutant lung cancer

B Yuan, MJ Clowers, WV Velasco, S Peng, Q Peng… - JCI insight, 2022 - ncbi.nlm.nih.gov
K-ras–mutant lung adenocarcinoma (KM-LUAD) is associated with abysmal prognosis and
is tightly linked to tumor-promoting inflammation. A human mAb, canakinumab, targeting the …

Serum IL-1β and IL-17 levels in patients with COPD: associations with clinical parameters

Y Zou, X Chen, J Liu, DB Zhou, X Kuang… - … journal of chronic …, 2017 - Taylor & Francis
COPD is a chronic airway inflammatory disease characterized mainly by neutrophil airway
infiltrations. Interleukin (IL)-1β and IL-17 are the key mediators of neutrophilic airway …

[HTML][HTML] Orchestration of neutrophil extracellular traps (Nets), a unique innate immune function during chronic obstructive pulmonary disease (COPD) development

A Trivedi, MA Khan, G Bade, A Talwar - Biomedicines, 2021 - mdpi.com
Morbidity, mortality and economic burden caused by chronic obstructive pulmonary disease
(COPD) is a significant global concern. Surprisingly, COPD is already the third leading …

Influenza A virus infection causes chronic lung disease linked to sites of active viral RNA remnants

SP Keeler, EV Agapov, ME Hinojosa… - The Journal of …, 2018 - journals.aai.org
Clinical and experimental observations suggest that chronic lung disease is linked to
respiratory viral infection. However, the long-term aspect of this relationship is not yet …

New insights into the role of NLRP3 inflammasome in pathogenesis and treatment of chronic obstructive pulmonary disease

J Zhang, Q Xu, W Sun, X Zhou, D Fu… - Journal of inflammation …, 2021 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease
characterized by chronic airway obstruction and emphysema. Accumulating studies have …

Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations

O Le Rouzic, M Pichavant, E Frealle… - European …, 2017 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the
airways caused mainly by cigarette smoke exposure. COPD progression is marked by …

Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy

BS Pollard, JC Blanco, JR Pollard - in vivo, 2020 - iv.iiarjournals.org
Background/Aim: Influenza viruses, corona viruses and related pneumotropic viruses cause
sickness and death partly by inducing cytokine storm, a hyper-proinflammatory host …

[HTML][HTML] Simvastatin suppresses airway IL-17 and upregulates IL-10 in patients with stable COPD

K Maneechotesuwan, A Wongkajornsilp, IM Adcock… - Chest, 2015 - Elsevier
BACKGROUND Statins have immunomodulatory properties that may provide beneficial
effects in the treatment of COPD. We investigated whether a statin improves the IL-17/IL-10 …