The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …

The Electrospray Ionization (ESI) is a soft ionization technique extensively used for
production of gas phase ions (without fragmentation) of thermally labile large …

Neutralization-reionization mass spectrometry (MS) 1 is of unique value for preparing and
characterizing highly reactive and unstable neutral species, such as the intermediate in the …

Photodissociation mass spectrometry combines the ability to activate and fragment ions
using photons with the sensitive detection of the resulting product ions by mass …

The top-down approach to proteomics offers compelling advantages due to the potential to
provide complete characterization of protein sequence and post-translational modifications …

Mass spectrometry (MS)–based high-throughput proteomics is the core technique for large-
scale protein characterization. Due to the extreme complexity of proteomes, sophisticated …

For proteins of< 20 kDa, this new radical site dissociation method cleaves different and
many more backbone bonds than the conventional MS/MS methods (eg, collisionally …

Technological and scientific advances over the past decade have enabled protein
identification and characterization strategies to be developed that are based on subjecting …

Tandem mass spectrometry (MS/MS) of 28 residue peptides harboring γ-carboxylated
glutamic acid residues, a posttranslational modification of several proenzymes of the blood …

Mass spectrometric identification of all types of molecules relies on the observation and
interpretation of ion fragmentation patterns. Peptides, proteins, carbohydrates, and nucleic …