Modern viral kinetic modeling and its application to therapeutics is a field that attracted the
attention of the medical, pharmaceutical, and modeling communities during the early days of …

PEGylation is a clinically proven strategy for increasing the therapeutic efficacy of protein-
based medicines. Our approach to site-specific PEGylation exploits the thiol selective …

Highly active antiretroviral therapy (HAART) can control HIV-1 replication,, but suboptimal
treatment allows for the evolution of resistance and rebound viremia,,,,,. A comparative …

Viral kinetic (VK) modeling has led to increased understanding of the within host dynamics
of viral infections and the effects of therapy. Here we review recent developments in the …

Understanding the mechanisms governing host-pathogen kinetics is important and can
guide human interventions. In-host mathematical models, together with biological data, have …

The current paradigm for studying hepatitis C virus (HCV) dynamics in patients utilizes a
standard viral dynamic model that keeps track of uninfected (target) cells, infected cells, and …

Mathematically modelling changes in HCV RNA levels measured in patients who receive
antiviral therapy has yielded many insights into the pathogenesis and effects of treatment on …

PEGylation is the covalent conjugation of PEG to therapeutic molecules. Protein PEGylation
is a clinically proven approach for extending the circulation half-life and reducing the …

PEGylation has turned proteins into important new biopharmaceuticals. The fundamental
problems with the existing approaches to PEGylation are inefficient conjugation and the …

Hepatitis C virus (HCV) infection remains a threat to global public health. Treatment with
pegylated interferon (IFN) plus ribavirin leads to a sustained virologic response in about …