RhoA is a ubiquitously expressed cytoplasmic protein that belongs to the family of small
GTPases. RhoA acts as a molecular switch that is activated in response to binding of …

Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …

Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate
and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into …

The ubiquitously expressed phosphoinositide 3-kinase (PI3K) family of lipid kinases control
diverse cellular functions including cell survival, proliferation, metabolism and migration …

Macropinocytosis has long been known as a primary method for cellular intake of fluid-
phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies …

Actin plays a critical role during the early stages of pathogenic microbe internalization by
immune cells. In this study, we identified a key mechanism of actin filament tethering and …

Dendritic cells are potent antigen-presenting cells endowed with the unique ability to initiate
adaptive immune responses upon inflammation. Inflammatory processes are often …

In this review, we summarize the mechanisms by which sphingolipids modulate virus
multiplication and the host innate immune response, using a number of host-virus systems …

Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact
hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and …

Dendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The major
functions of these antigen-presenting cells are the capture, endosomal processing and …