Abstract The World Health Organization (WHO) has declared coronavirus disease 2019
(COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 …

Clinically significant bleeding can occur as a consequence of surgery, trauma, obstetric
complications, anticoagulation, and a wide variety of disorders of hemostasis. As the causes …

Background Post-partum haemorrhage is the leading cause of maternal death worldwide.
Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients …

1NHS Blood and Transplant, 2Imperial College Healthcare NHS Trust, London, 3University
College Hospitals NHS Trust, London, 4Serious Hazards of Transfusion, NHS Blood and …

Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or
prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding …

There has been an explosion of interest in the ability of tranexamic acid to reduce morbidity
and mortality in surgical and traumatic bleeding. Tranexamic acid has been shown to reduce …

Background context Spine surgery is usually associated with large amount of blood loss,
necessitating blood transfusions. Blood loss-associated morbidity can be because of direct …

Bleeding is a common problem in cancer patients, related to local tumor invasion, tumor
angiogenesis, systemic effects of the cancer, or anti-cancer treatments. Existing bleeds can …

In major surgery, the implementation of multidisciplinary, multimodal and individualized
strategies, collectively termed Patient Blood Management, aims to identify modifiable risks …

Background Reducing operative blood loss improves patient outcomes and reduces
healthcare costs. The aim of this article was to review current surgical, anaesthetic and …