The neurogenesis hypothesis of affective and anxiety disorders: are we mistaking the scaffolding for the building?

D Petrik, DC Lagace, AJ Eisch - Neuropharmacology, 2012 - Elsevier
Hypotheses are scaffoldings erected in front of a building and then dismantled when the
building is finished. They are indispensable for the workman; but you mustn't mistake the …

Age, plasticity, and homeostasis in childhood brain disorders

M Dennis, BJ Spiegler, JJ Juranek, ED Bigler… - Neuroscience & …, 2013 - Elsevier
It has been widely accepted that the younger the age and/or immaturity of the organism, the
greater the brain plasticity, the young age plasticity privilege. This paper examines the …

Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche

P Codega, V Silva-Vargas, A Paul… - Neuron, 2014 - cell.com
Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …

Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits

S Jung, S Choe, H Woo, H Jeong, HK An, H Moon… - Autophagy, 2020 - Taylor & Francis
Macroautophagy/autophagy is generally regarded as a cytoprotective mechanism, and it
remains a matter of controversy whether autophagy can cause cell death in mammals. Here …

Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

T Kobayashi, W Piao, T Takamura, H Kori… - Nature …, 2019 - nature.com
Quiescence is important for sustaining neural stem cells (NSCs) in the adult brain over the
lifespan. Lysosomes are digestive organelles that degrade membrane receptors after they …

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

DC Berry, Y Jiang, JM Graff - Nature communications, 2016 - nature.com
Cold temperatures induce formation of beige adipocytes, which convert glucose and fatty
acids to heat, and may increase energy expenditure, reduce adiposity and lower blood …

FACS isolation of endothelial cells and pericytes from mouse brain microregions

EE Crouch, F Doetsch - Nature protocols, 2018 - nature.com
The vasculature is emerging as a key contributor to brain function during neurodevelopment
and in mature physiological and pathological states. The brain vasculature itself also …

Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning

M Sakamoto, N Ieki, G Miyoshi… - Journal of …, 2014 - Soc Neuroscience
The olfactory bulb (OB) is one of the two major loci in the mammalian brain where newborn
neurons are constantly integrated into the neural circuit during postnatal life. Newborn …

Adult hippocampal neurogenesis modulates fear learning through associative and nonassociative mechanisms

D Seo, MA Carillo, SCH Lim, KF Tanaka… - Journal of …, 2015 - Soc Neuroscience
Adult hippocampal neurogenesis is believed to support hippocampus-dependent learning
and emotional regulation. These putative functions of adult neurogenesis have typically …

The functional significance of newly born neurons integrated into olfactory bulb circuits

M Sakamoto, R Kageyama, I Imayoshi - Frontiers in neuroscience, 2014 - frontiersin.org
The olfactory bulb (OB) is the first central processing center for olfactory information
connecting with higher areas in the brain, and this neuronal circuitry mediates a variety of …