The life-cycle of the HIV-1 Gag–RNA complex
E Mailler, S Bernacchi, R Marquet, JC Paillart… - Viruses, 2016 - mdpi.com
Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process
requiring the recruitment of viral and cellular components to the plasma membrane for …
requiring the recruitment of viral and cellular components to the plasma membrane for …
Retroviral RNA dimerization: from structure to functions
N Dubois, R Marquet, JC Paillart… - Frontiers in …, 2018 - frontiersin.org
The genome of the retroviruses is a dimer composed by two homologous copies of genomic
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …
Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesis
SB Kutluay, T Zang, D Blanco-Melo, C Powell… - Cell, 2014 - cell.com
The HIV-1 Gag protein orchestrates all steps of virion genesis, including membrane
targeting and RNA recruitment into virions. Using crosslinking-immunoprecipitation (CLIP) …
targeting and RNA recruitment into virions. Using crosslinking-immunoprecipitation (CLIP) …
Nano-DMS-MaP allows isoform-specific RNA structure determination
Genome-wide measurements of RNA structure can be obtained using reagents that react
with unpaired bases, leading to adducts that can be identified by mutational profiling on next …
with unpaired bases, leading to adducts that can be identified by mutational profiling on next …
Specific recognition of the HIV-1 genomic RNA by the Gag precursor
EW Abd El-Wahab, RP Smyth, E Mailler… - Nature …, 2014 - nature.com
During assembly of HIV-1 particles in infected cells, the viral Pr55Gag protein (or Gag
precursor) must select the viral genomic RNA (gRNA) from a variety of cellular and viral …
precursor) must select the viral genomic RNA (gRNA) from a variety of cellular and viral …
Short-and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging
RNA dimerization is the noncovalent association of two human immunodeficiency virus-1
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
Epitranscriptomic regulation of HIV-1 full-length RNA packaging
C Pereira-Montecinos, D Toro-Ascuy… - Nucleic Acids …, 2022 - academic.oup.com
During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA.
However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules …
However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules …
HIV infection and HERV expression: a review
AC van der Kuyl - Retrovirology, 2012 - Springer
The human genome contains multiple copies of retrovirus genomes known as endogenous
retroviruses (ERVs) that have entered the germ-line at some point in evolution. Several of …
retroviruses (ERVs) that have entered the germ-line at some point in evolution. Several of …
Plasma-derived HIV-1 virions contain considerable levels of defective genomes
K Fisher, XQ Wang, A Lee, V Morcilla… - Journal of …, 2022 - Am Soc Microbiol
Genetically-characterizing full-length HIV-1 RNA is critical for identifying genetically-intact
genomes and for comparing these RNA genomes to proviral DNA. We have developed a …
genomes and for comparing these RNA genomes to proviral DNA. We have developed a …
Dynamic nanopore long-read sequencing analysis of HIV-1 splicing events during the early steps of infection
N Nguyen Quang, S Goudey, E Ségéral, A Mohammad… - Retrovirology, 2020 - Springer
Background Alternative splicing is a key step in Human Immunodeficiency Virus type 1 (HIV-
1) replication that is tightly regulated both temporally and spatially. More than 50 different …
1) replication that is tightly regulated both temporally and spatially. More than 50 different …