As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity
and substantial population structure. Importantly, African genomes are heterogeneous: They …

Background Although pockets of bioinformatics excellence have developed in Africa,
generally, large-scale genomic data analysis has been limited by the availability of expertise …

Abstract The Southern African Human Genome Programme is a national initiative that
aspires to unlock the unique genetic character of southern African populations for a better …

Abstract Background: Toll-like receptors (TLRs) are involved in the recognition of conserved
microbial structures, leading to activation of an inflammatory response and formation of an …

Admixture is a well known confounder in genetic association studies. If genome-wide data is
not available, as would be the case for candidate gene studies, ancestry informative markers …

Genetic variation and susceptibility to disease are shaped by human demographic history
and adaptation. We can now study the genomes of extant Africans and uncover traces of …

Over the past decade, studies of admixed populations have increasingly gained interest in
both medical and population genetics. These studies have so far shed light on the patterns …

We report a study of genome-wide, dense SNP (∼ 900K) and copy number polymorphism
data of indigenous southern Africans. We demonstrate the genetic contribution to southern …

Background Global and local ancestry inference in admixed human populations can be
performed using computational tools implementing distinct algorithms. The development …

HIV infection continues to be a major global public health issue. The population
heterogeneity in susceptibility or resistance to HIV-1 and progression upon infection is …