Ocular drug delivery to the retina: current innovations and future perspectives

HM Kim, SJ Woo - Pharmaceutics, 2021 - mdpi.com
Treatment options for retinal diseases, such as neovascular age-related macular
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …

[HTML][HTML] Expert opinion on management of intraocular inflammation, retinal vasculitis, and vascular occlusion after brolucizumab treatment

CR Baumal, B Bodaghi, M Singer, DJ Tanzer… - Ophthalmology …, 2021 - Elsevier
Purpose Recent reports have described a spectrum of uncommon findings of intraocular
inflammation (IOI), retinal vasculitis and/or retinal vascular occlusion in patients with …

Safety outcomes of brolucizumab in neovascular age-related macular degeneration: results from the IRIS Registry and Komodo Healthcare Map

AM Khanani, MA Zarbin, MR Barakat… - JAMA …, 2022 - jamanetwork.com
Importance Limited data exist on the real-world safety outcomes of patients with neovascular
age-related macular degeneration treated with brolucizumab (Beovu). Objective To …

Short-term real-world outcomes following intravitreal brolucizumab for neovascular AMD: SHIFT study

LM Bulirsch, M Saßmannshausen, J Nadal… - British Journal of …, 2022 - bjo.bmj.com
Background Brolucizumab has recently been approved in Europe as a novel treatment for
patients with neovascular age-related macular degeneration (nAMD). We report on early …

Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review

WJ Anderson, NFS da Cruz, LH Lima… - International journal of …, 2021 - Springer
Background Intraocular inflammation is an uncommon but potentially vision-threatening
adverse event related to anti-VEGF therapy. This is of increasing importance given both the …

Short-term outcomes of intravitreal brolucizumab for treatment-naïve neovascular age-related macular degeneration with type 1 choroidal neovascularization …

H Matsumoto, J Hoshino, R Mukai, K Nakamura… - Scientific Reports, 2021 - nature.com
We evaluated the efficacy and safety of loading phase treatment with intravitreal
brolucizumab for neovascular age-related macular degeneration (nAMD) with type 1 …

Complications of intravitreal injections: 2022

D Patel, SN Patel, V Chaudhary… - Current Opinion in …, 2022 - journals.lww.com
Intravitreal injections continue to be one of the most commonly performed procedures by
ophthalmologists. Although the injections are generally well tolerated, sight-threatening …

Early experience with brolucizumab treatment of neovascular age-related macular degeneration

AB Enríquez, CR Baumal, AM Crane… - JAMA …, 2021 - jamanetwork.com
Importance Outcome data are limited regarding early experience with brolucizumab, the
most recently approved anti–vascular endothelial growth factor (VEGF) agent for the …

Inflammatory complications of intravitreal anti-VEGF injections

JT Cox, D Eliott, L Sobrin - Journal of Clinical Medicine, 2021 - mdpi.com
Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents is a
commonly used therapy for numerous retinal diseases. The most commonly used of these …

Risk factors for emerging intraocular inflammation after intravitreal brolucizumab injection for age-related macular degeneration

R Mukai, H Matsumoto, H Akiyama - PLoS One, 2021 - journals.plos.org
Purpose To analyze the risk factors associated with emerging intraocular inflammation (IOI)
after intravitreal brolucizumab injection (IVBr) to treat age-related macular degeneration …