Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …

The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

Sex determining region Y-box 2 (Sox2), a member of the SoxB1 transcription factor family, is
an important transcriptional regulator in pluripotent stem cells (PSCs). Together with octamer …

Research of the past view years expanded our understanding of the various physiological
functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis …

Direct reprogramming of somatic cells provides an opportunity to generate patient-or
disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were …

The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the
ability to differentiate into virtually all adult cell types are not well understood. Polycomb …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the …

Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in
neoplastic development. Their oncogenic function might be associated with their well …