Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …

ABSTRACT Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6
family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B …

Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …

Summary KRAS G12C inhibitors (adagrasib and sotorasib) have shown clinical promise in
targeting KRAS G12C-mutated lung cancers; however, most patients eventually develop …

Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, encoded by
KDM6A) is a histone demethylase that targets di-and tri-methylated histone H3 lysine 27 …

Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However,
we are currently unaware of any studies using selective and potent ClpP activators in lung …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Lung cancer is the leading cause of cancer mortality in both genders, with non-small cell
lung cancer (NSCLC) accounting for about 85% of all lung cancers. At the time of diagnosis …

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …