Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution
MR Gillings, WH Gaze, A Pruden, K Smalla… - The ISME …, 2015 - academic.oup.com
Around all human activity, there are zones of pollution with pesticides, heavy metals,
pharmaceuticals, personal care products and the microorganisms associated with human …
pharmaceuticals, personal care products and the microorganisms associated with human …
Integrons: past, present, and future
MR Gillings - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …
[HTML][HTML] IntegronFinder 2.0: identification and analysis of integrons across bacteria, with a focus on antibiotic resistance in Klebsiella
Integrons are flexible gene-exchanging platforms that contain multiple cassettes encoding
accessory genes whose order is shuffled by a specific integrase. Integrons embedded within …
accessory genes whose order is shuffled by a specific integrase. Integrons embedded within …
Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites
Integrons are genetic elements involved in bacterial adaptation which capture, shuffle and
express genes encoding adaptive functions embedded in cassettes. These events are …
express genes encoding adaptive functions embedded in cassettes. These events are …
[HTML][HTML] Antibiotic resistance in Vibrio cholerae: understanding the ecology of resistance genes and mechanisms
The unique genetic makeup and remarkable competency of Vibrio cholerae are the key
factors that help the cholera pathogen adapt rapidly to adverse environmental conditions …
factors that help the cholera pathogen adapt rapidly to adverse environmental conditions …
Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens
HW Stokes, MR Gillings - FEMS microbiology reviews, 2011 - academic.oup.com
Antibiotics were one of the great discoveries of the 20th century. However, resistance
appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to …
appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to …
Integrons: agents of bacterial evolution
D Mazel - Nature Reviews Microbiology, 2006 - nature.com
Integrons are assembly platforms—DNA elements that acquire open reading frames
embedded in exogenous gene cassettes and convert them to functional genes by ensuring …
embedded in exogenous gene cassettes and convert them to functional genes by ensuring …
Gene cassettes and cassette arrays in mobile resistance integrons
Gene cassettes are small mobile elements, consisting of little more than a single gene and
recombination site, which are captured by larger elements called integrons. Several …
recombination site, which are captured by larger elements called integrons. Several …
Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations
R López-Igual, J Bernal-Bayard… - Nature …, 2019 - nature.com
Targeted killing of pathogenic bacteria without harming beneficial members of host
microbiota holds promise as a strategy to cure disease and limit both antimicrobial-related …
microbiota holds promise as a strategy to cure disease and limit both antimicrobial-related …