Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution

MR Gillings, WH Gaze, A Pruden, K Smalla… - The ISME …, 2015 - academic.oup.com
Around all human activity, there are zones of pollution with pesticides, heavy metals,
pharmaceuticals, personal care products and the microorganisms associated with human …

Integrons: past, present, and future

MR Gillings - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …

[HTML][HTML] IntegronFinder 2.0: identification and analysis of integrons across bacteria, with a focus on antibiotic resistance in Klebsiella

B Néron, E Littner, M Haudiquet, A Perrin, J Cury… - Microorganisms, 2022 - mdpi.com
Integrons are flexible gene-exchanging platforms that contain multiple cassettes encoding
accessory genes whose order is shuffled by a specific integrase. Integrons embedded within …

Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites

C Loot, GA Millot, E Richard, E Littner, C Vit… - Nature …, 2024 - nature.com
Integrons are genetic elements involved in bacterial adaptation which capture, shuffle and
express genes encoding adaptive functions embedded in cassettes. These events are …

[HTML][HTML] Antibiotic resistance in Vibrio cholerae: understanding the ecology of resistance genes and mechanisms

B Das, J Verma, P Kumar, A Ghosh, T Ramamurthy - Vaccine, 2020 - Elsevier
The unique genetic makeup and remarkable competency of Vibrio cholerae are the key
factors that help the cholera pathogen adapt rapidly to adverse environmental conditions …

Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens

HW Stokes, MR Gillings - FEMS microbiology reviews, 2011 - academic.oup.com
Antibiotics were one of the great discoveries of the 20th century. However, resistance
appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to …

Integrons: agents of bacterial evolution

D Mazel - Nature Reviews Microbiology, 2006 - nature.com
Integrons are assembly platforms—DNA elements that acquire open reading frames
embedded in exogenous gene cassettes and convert them to functional genes by ensuring …

Integrons

G Cambray, AM Guerout, D Mazel - Annual review of genetics, 2010 - annualreviews.org
Integrons are genetic elements able to acquire and rearrange open reading frames (ORFs)
embedded in gene cassette units and convert them to functional genes by ensuring their …

Gene cassettes and cassette arrays in mobile resistance integrons

SR Partridge, G Tsafnat, E Coiera… - FEMS microbiology …, 2009 - academic.oup.com
Gene cassettes are small mobile elements, consisting of little more than a single gene and
recombination site, which are captured by larger elements called integrons. Several …

Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations

R López-Igual, J Bernal-Bayard… - Nature …, 2019 - nature.com
Targeted killing of pathogenic bacteria without harming beneficial members of host
microbiota holds promise as a strategy to cure disease and limit both antimicrobial-related …