Titin is a filamentous protein spanning the half-sarcomere, with spring-like properties in the I-
band region. Various structural, signaling, and mechanical functions have been associated …

This nonexhaustive mini-review reports on the application of eccentric exercise in various
rehabilitation populations. The two defining properties of eccentric muscle contractions—a …

In contrast to isometric and shortening contractions, many observations made on actively
lengthening muscles cannot be readily explained with the sliding filament and cross-bridge …

When active muscles are stretched, our understanding of muscle function is stretched as
well. Our understanding of the molecular mechanisms of concentric contraction has …

For the past 60 years, muscle contraction had been thought to be governed exclusively by
the contractile filaments, actin, and myosin. This thinking explained most observations for …

Muscle contraction and force regulation in skeletal muscle have been thought to occur
exclusively through the relative sliding of and the interaction between the contractile …

Eccentric muscle properties are not well characterized by the current paradigm of the
molecular mechanism of contraction: the cross-bridge theory. Findings of force contributions …

During the past century, physiologists have made steady progress in elucidating the
molecular mechanisms of muscle contraction. However, this progress has so far failed to …

Despite an age-related loss of voluntary isometric and concentric strength, muscle strength
is well maintained during lengthening muscle actions (ie, eccentric strength) in old age …

The sliding filament theory of muscle contraction is widely accepted as the means by which
muscles generate force during activation. Within the constraints of this theory, isometric …