Current understanding of pathogenesis and treatment of TMJ osteoarthritis

XD Wang, JN Zhang, YH Gan… - Journal of dental …, 2015 - journals.sagepub.com
Osteoarthritis is a common disease that can cause severe pain and dysfunction in any joint,
including the temporomandibular joint (TMJ). TMJ osteoarthritis (TMJOA) is an important …

Pathophysiology of TMD pain–basic mechanisms and their implications for pharmacotherapy

BE Cairns - Journal of oral rehabilitation, 2010 - Wiley Online Library
This article discusses the pathophysiology of temporomandibular disorders (TMD)‐related
pain and its treatment with analgesic drugs. Temporomandibular disorders are comprised of …

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

S Zhang, KYW Teo, SJ Chuah, RC Lai, SK Lim… - Biomaterials, 2019 - Elsevier
The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to
paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC …

Temporomandibular joint osteoarthritis: pathogenic mechanisms involving the cartilage and subchondral bone, and potential therapeutic strategies for joint …

A Cardoneanu, LA Macovei, AM Burlui… - International Journal of …, 2022 - mdpi.com
The temporomandibular joint (TMJ) is a specialized synovial joint that is crucial for the
movement and function of the jaw. TMJ osteoarthritis (TMJ OA) is the result of disc …

An emerging player in knee osteoarthritis: the infrapatellar fat pad

A Ioan-Facsinay, M Kloppenburg - Arthritis research & therapy, 2013 - Springer
The role of inflammation in the development, progression, and clinical features of
osteoarthritis has become an area of intense research in recent years. This led to the …

[HTML][HTML] Molecular signaling in temporomandibular joint osteoarthritis

K Lu, F Ma, D Yi, H Yu, L Tong, D Chen - Journal of orthopaedic translation, 2022 - Elsevier
Objective Temporomandibular joint (TMJ) osteoarthritis (OA) is a type of TMJ disorders with
clinical symptoms of pain, movement limitation, cartilage degeneration and joint dysfunction …

Regulatory T cell phenotype and anti-osteoclastogenic function in experimental periodontitis

C Alvarez, S Suliman, R Almarhoumi, ME Vega… - Scientific Reports, 2020 - nature.com
The alveolar bone resorption is a distinctive feature of periodontitis progression and
determinant for tooth loss. Regulatory T lymphocytes (Tregs) display immuno-suppressive …

[HTML][HTML] Upregulation of lncRNA HOTAIR contributes to IL-1β-induced MMP overexpression and chondrocytes apoptosis in temporomandibular joint osteoarthritis

C Zhang, P Wang, P Jiang, Y Lv, C Dong, X Dai, L Tan… - Gene, 2016 - Elsevier
Temporomandibular joint osteoarthritis (TMJ OA) is a common and heterogeneous disease
that causes painful and progressive joint degeneration, which restricts daily activities …

Osteoimmunology of oral and maxillofacial diseases: translational applications based on biological mechanisms

C Alvarez, G Monasterio, F Cavalla… - Frontiers in …, 2019 - frontiersin.org
The maxillofacial skeleton is highly dynamic and requires a constant equilibrium between
the bone resorption and bone formation. The field of osteoimmunology explores the …

TMD and chronic pain: a current view

BDA Furquim, LMSP Flamengui… - Dental press journal of …, 2015 - SciELO Brasil
This review aims at presenting a current view on the physiopathologic mechanisms
associated with temporomandibular disorders (TMDs). While joint pain is characterized by a …