[HTML][HTML] The relationship between circulating testosterone and inflammatory cytokines in men

NV Mohamad, SK Wong, WNW Hasan, JJ Jolly… - The Aging …, 2019 - Taylor & Francis
Testosterone is the predominant gonadal androgen in men. Low testosterone levels are
found to be associated with an increased in metabolic risk and systematic inflammation …

Sex‐based differences in severity and mortality in COVID‐19

M Alwani, A Yassin, RM Al‐Zoubi… - Reviews in Medical …, 2021 - Wiley Online Library
The current coronavirus disease (COVID‐19) pandemic caused by novel severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has a male bias in severity and …

[HTML][HTML] An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance

M He, HH Chiang, H Luo, Z Zheng, Q Qiao, L Wang… - Cell metabolism, 2020 - cell.com
It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …

Age-dependent dysregulation of innate immunity

AC Shaw, DR Goldstein, RR Montgomery - Nature Reviews …, 2013 - nature.com
As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …

Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis

GJ Grosicki, RA Fielding, MS Lustgarten - Calcified tissue international, 2018 - Springer
Skeletal muscle is a highly plastic tissue that plays a central role in human health and
disease. Aging is associated with a decrease in muscle mass and function (sarcopenia) that …

Testosterone and obesity

DM Kelly, TH Jones - Obesity Reviews, 2015 - Wiley Online Library
Testosterone is a key hormone in the pathology of metabolic diseases such as obesity. Low
testosterone levels are associated with increased fat mass (particularly central adiposity) …

The confluence of sex hormones and aging on immunity

MR Gubbels Bupp, T Potluri, AL Fink… - Frontiers in …, 2018 - frontiersin.org
The immune systems of post-pubescent males and females differ significantly with profound
consequences to health and disease. In many cases, sex-specific differences in the immune …

[HTML][HTML] Testosterone: a metabolic hormone in health and disease

DM Kelly, TH Jones - Journal of Endocrinology, 2013 - joe.bioscientifica.com
Testosterone is a hormone that plays a key role in carbohydrate, fat and protein metabolism.
It has been known for some time that testosterone has a major influence on body fat …

The role of adiponectin in cancer: a review of current evidence

M Dalamaga, KN Diakopoulos… - Endocrine …, 2012 - academic.oup.com
Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

The anti-inflammatory effects of testosterone

VE Bianchi - Journal of the endocrine society, 2019 - academic.oup.com
Low plasma testosterone (T) levels correlated with metabolic syndrome, cardiovascular
diseases, and increased mortality risk. T exerts a significant effect on the regulation of …