Alterations in histology of the aging salivary gland and correlation with the glandular inflammatory microenvironment

N Li, Y Ye, Y Wu, L Li, J Hu, D Luo, Y Li, J Yang, Y Gao… - IScience, 2023 - cell.com
Aging-related salivary dysfunction typically causes reduced saliva volumes, which leads to
debilitating consequences, even affecting patient quality of life. Understanding the …

Highly localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion

T Takano, AM Wahl, KT Huang, T Narita, J Rugis… - Elife, 2021 - elifesciences.org
Salivary fluid secretion involves an intricate choreography of membrane transporters to
result in the trans-epithelial movement of NaCl and water into the acinus lumen. Current …

Calcium dynamics and water transport in salivary acinar cells

J Sneyd, E Vera-Sigüenza, J Rugis, N Pages… - Bulletin of mathematical …, 2021 - Springer
Saliva is secreted from the acinar cells of the salivary glands, using mechanisms that are
similar to other types of water-transporting epithelial cells. Using a combination of theoretical …

[HTML][HTML] Simulation of Calcium Dynamics in Realistic Three-Dimensional Domains

J Sneyd, J Rugis, S Su, V Suresh, AM Wahl, DI Yule - Biomolecules, 2022 - mdpi.com
The cytosolic concentration of free calcium ions ([Ca 2+]) is an important intracellular
messenger in most cell types, and the spatial distribution of [Ca 2+] is often critical. In a …

Expression of BK channels and Na+-K+ pumps in the apical membrane of lacrimal acinar cells suggests a new molecular mechanism for primary tear-secretion

J Almássy, G Diszházi, M Skaliczki, I Márton… - The ocular …, 2019 - Elsevier
Purpose Primary fluid secretion in secretory epithelia relies on the unidirectional transport of
ions and water across a single cell layer. This mechanism requires the asymmetric apico …

酸刺激对腮腺和下颌下腺唾液流率及成分的影响

陈超伦, 苏家增, 俞光岩 - Journal of Peking University (Health …, 2021 - pmc.ncbi.nlm.nih.gov
目的探讨酸刺激对腮腺和下颌下腺唾液流率及成分的影响, 为全面评估健康和疾病状态时的
唾液腺功能提供依据. 方法采用自然留取法收集210 名健康志愿者在静息状态下的全唾液 …

A mathematical model of fluid transport in an accurate reconstruction of parotid acinar cells

E Vera-Sigüenza, N Pages, J Rugis, DI Yule… - Bulletin of mathematical …, 2019 - Springer
Salivary gland acinar cells use the calcium (Ca^ 2+ Ca 2+) ion as a signalling messenger to
regulate a diverse range of intracellular processes, including the secretion of primary saliva …

氟啶虫酰胺作用靶标—内向整流钾离子通道研究进展

苏建亚 - 农药学学报, 2019 - nyxxb.cn
氟啶虫酰胺是一种高选择性杀虫剂, 主要用于防治刺吸式口器害虫. 有关该杀虫剂的分子靶标
长期未知. 近年来随着研究的逐渐深入, 相关作用靶标已逐步得到明确. 早期研究表明 …

Effects of acid stimulation on saliva flow rate and compositions of human parotid and submandibular glands

CL Chen, JZ Su, GY Yu - Beijing da xue xue bao. Yi xue ban …, 2022 - europepmc.org
Objective To investigate the effect of acid stimulation on salivary flow rate and compositions
of human parotid and submandibular glands, so as to provide basis for comprehensive …

The characteristics of intracellular Ca2+ signals in vivo necessitate a new model for salivary fluid secretion

T Takano, AM Wahl, KT Huang, J Rugis, J Sneyd… - bioRxiv, 2021 - biorxiv.org
Salivary fluid secretion involves an intricate choreography to result in the trans-epithelial
movement of NaCl and water into the acinus lumen. Current models are based on …