Abstract Cytidine‐5′‐diphosphocholine (citicoline or CDP‐choline), an intermediate in the
biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of …

This review is based on the previous one published in 2010–Secades JJ. Citicoline:
pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62 …

Cytidine 5'-diphosphocholine, CDP-choline, or citicoline is an essential intermediate in the
biosynthetic pathway of structural phospholipids in cell membranes, particularly …

CDP-choline, supplied exogenously as citicoline, has beneficial physiological actions on
cellular function that have been extensively studied and characterized in numerous model …

Citicoline, an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown
beneficial effects in various CNS injury models and neurodegenerative diseases. PtdCho …

Complete prevention of the killing of L929 fibroblasts by tumor necrosis factor α (TNF) in the
presence of 0.5 μg/ml actinomycin D (ActD) was obtained with cyclosporin A (CyA), an …

Phospholipid degradation is an important promoter of neuronal death after transient cerebral
ischemia. Phospholipid hydrolysis by phospholipase A2 (PLA2) after transient cerebral …

Head injury is among the most devastating types of injury, specifically called Traumatic Brain
Injury (TBI). There is a need to diminish the morbidity related with TBI and to improve the …

Background and Purpose—Cytidine-5′-diphosphocholine (citicoline or CDP-choline) is an
essential intermediate in the biosynthesis of phosphatidylcholine, an important component …

Neuroprotection by citicoline (CDP‐choline) in transient cerebral ischemia has been
demonstrated previously. Citicoline has undergone several Phase III clinical trials for stroke …