The abuse of illicit psychostimulants such as cocaine and methamphetamine continues to
pose significant health and societal challenges. Despite considerable efforts to develop …

The beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE‐1) initiates the
generation of amyloid‐β (Aβ), and the amyloid cascade leading to amyloid plaque …

Drug-induced blockade of the human ether-à-go-go-related gene (hERG) channel is today
considered the main cause of cardiotoxicity in postmarketing surveillance. Hence, several …

The human ether-a-go-go (hERG) potassium channel (K v 11. 1) plays a critical role in
mediating cardiac action potential. The blockade of this ion channel can potentially lead fatal …

Molecular dynamics (MD) simulations allow researchers to investigate the behavior of
desired biological targets at ever-decreasing costs with ever-increasing precision. Among …

The Kv11. 1 potassium channel, encoded by the human ether-a-go-go-related gene (hERG),
plays an essential role in the cardiac action potential. hERG blockade by small molecules …

Off-target interactions of drugs with the human ether-à-go-go related gene 1 (hERG1)
channel have been associated with severe cardiotoxic conditions leading to the withdrawal …

Psychostimulant drugs, such as cocaine, inhibit dopamine reuptake via blockading the
dopamine transporter (DAT), which is the primary mechanism underpinning their abuse …

Currently, there are no FDA-approved medications for the treatment of psychostimulant use
disorders (PSUD). We have previously discovered “atypical” dopamine transporter (DAT) …

COVID-19 caused by a positive-sense single stranded RNA virus named as severe acute
respiratory syndrome-Coronavirus-2 (SARS-CoV-2) triggered the global pandemic. This …