Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …

Abstract Purpose of the Review In this review, we summarize current insights into the
versatile roles of endothelial cells in atherogenesis. Recent Findings The vascular …

To understand how the microvasculature grows and remodels, researchers require
reproducible systems that emulate the function of living tissue. Innovative contributions …

The advances in single-cell RNA sequencing technologies and the development of
bioinformatics pipelines enable us to more accurately define the heterogeneity of cell types …

Diabetic nephropathy remains a common cause of end-stage renal failure and its associated
mortality around the world. Sphingosine 1-phosphate (S1P) is a multifunctional lipid …

During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells
(LECs) at the growing front sprout by forming filopodia. Those tip cells are not exposed to …

High-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and
suppress inflammation, but their utility in treating EC dysfunction has not been fully explored …

Endocardial cells lining the heart lumen are coronary vessel progenitors during
embryogenesis. Re-igniting this developmental process in adults could regenerate blood …

The endothelium, the monolayer of endothelial cells that line blood vessels, is exposed to a
number of mechanical forces, including frictional shear flow, pulsatile stretching and …

NF-κB–mediated endothelial activation drives leukocyte recruitment and atherosclerosis, in
part through adhesion molecules Icam1 and Vcam1. The endothelium is primed for cytokine …