PTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles
in the maintenance of calcium and phosphate homeostasis as well as the development and …

Over the past 25 years, successive cloning of SLC34A1, SLC34A2 and SLC34A3, which
encode the sodium-dependent inorganic phosphate (Pi) cotransport proteins 2a–2c, has …

We analyzed the effects of an FGF‐23 injection in vivo. FGF‐23 caused a reduction in serum
1, 25‐dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D …

Elevated serum phosphate levels have been linked with vascular calcification and mortality
among dialysis patients. The relationship between phosphate and mortality has not been …

Chronic kidney disease–mineral and bone disorder (CKD-MBD) is associated with
secondary hyperparathyroidism (HPT) and serum elevations in the phosphaturic hormone …

Npt2 encodes a renal-specific, brush-border membrane Na+-phosphate (Pi) cotransporter
that is expressed in the proximal tubule where the bulk of filtered Pi is reabsorbed. Mice …

In this paper, we present a review of the current knowledge of calcium and phosphorus
metabolism as it relates to homeostatic mechanisms in poultry; contrasts with mammalian …

Fibroblast growth factor (FGF)-23 was identified as a causative factor of tumor-induced
osteomalacia and also as a responsible gene for autosomal dominant hypophosphatemic …

Klotho mutant mouse (kl-/-), a mouse model for human aging, exhibits various phenotypes in
a wide range of organs including arteriosclerosis, neural degeneration, skin and gonadal …

Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a rare disorder of
autosomal recessive inheritance that was first described in a large consanguineous Bedouin …