Working memory is the fundamental function by which we break free from reflexive input-
output reactions to gain control over our own thoughts. It has two types of mechanisms …

The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …

Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …

Working memory is thought to result from sustained neuron spiking. However, computational
models suggest complex dynamics with discrete oscillatory bursts. We analyzed local field …

Cognitive workload (CWL) is a fundamental concept in the assessment and monitoring of
human performance during cognitive tasks. Numerous studies have attempted to objectively …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Persistent spiking has been thought to underlie working memory (WM). However, virtually all
of the evidence for this comes from studies that averaged spiking across time and across …

Theta and gamma frequency oscillations occur in the same brain regions and interact with
each other, a process called cross-frequency coupling. Here, we review evidence for the …

Neural oscillations at different frequencies have recently been related to a wide range of
basic and higher cognitive processes. One possible role of oscillatory activity is to assure the …

Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …