Life emerges from thousands of biochemical processes occurring within a shared
intracellular environment. We have gained deep insights from in vitro reconstitution of …

The cell nucleus stores the genetic material essential for life, and provides the environment
for transcription, maintenance, and replication of the genome. Moreover, the nucleoplasm is …

ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …

The large-scale organization of the genome inside the cell nucleus is critical for the cell's
function. Chromatin—the functional form of DNA in cells—serves as a template for active …

Cell differentiation, the process by which stem cells become specialized cells, is associated
with chromatin reorganization inside the cell nucleus. Here, we measure the chromatin …

Cardiac muscle contraction is distinct from the contraction of other muscle types. The heart
continuously undergoes contraction–relaxation cycles throughout an animal's lifespan. It …

We discover a new type of nonequilibrium phase transition in a model of chromatin
dynamics, which accounts for the coherent motions that have been observed in experiment …

A growing list of diverse biological systems and their equally diverse functionalities provides
realizations of a paradigm of emergent behavior. In each of these biological systems …

Genomic regions can acquire heritable epigenetic states through unique histone
modifications, which lead to stable gene expression patterns without altering the underlying …

Fluid-structure interactions between active and passive components are important for many
biological systems to function. A particular example is chromatin in the cell nucleus, where …