In vitro human cell line models have been widely used for cancer pharmacogenomic studies
to predict clinical response, to help generate pharmacogenomic hypothesis for further …

Genetic variation influences the response of an individual to drug treatments. Understanding
this variation has the potential to make therapy safer and more effective by determining …

Resistance to ionizing radiation, a first-line therapy for many cancers, is a major clinical
challenge. Personalized prediction of tumor radiosensitivity is not currently implemented …

Individuals with Behçet's disease suffer from episodic inflammation often affecting the
orogenital mucosa, skin and eyes. To discover new susceptibility loci for Behçet's disease …

DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with
the consequences of treatment, and toxicity in a minority limits the radiation doses that can …

Normal-tissue adverse effects following radiotherapy are common and significantly affect
quality of life. These effects cannot be accounted for by dosimetric, treatment, or …

Epstein–Barr virus (EBV) transformed lymphoblastoid cell lines (LCLs) provide a
conveniently accessible and renewable resource for functional genomic studies in humans …

Millions of patients suffer from major depressive disorder (MDD), but many do not respond to
selective serotonin reuptake inhibitor (SSRI) therapy. We used a pharmacometabolomics …