Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

In the medical literature the term 'mitochondrial disorders' is to a large extent applied to the
clinical syndromes associated with abnormalities of the common final pathway of …

Offering comprehensive coverage of a wide range of topics, this practical" how to" manual
explores and teaches methods that enhance good local anesthesia practices, while alerting …

Collagen VI is an extracellular matrix protein that forms a microfilamentous network in
skeletal muscles and other organs,,. Inherited mutations in genes encoding collagen VI in …

Small molecule mitochondrial uncouplers transport protons from the mitochondrial inner
membrane space into the mitochondrial matrix independent of ATP synthase, uncoupling …

In skeletal muscle, two major types of muscle fibers exist: slow-twitch oxidative (type I) fibers
designed for low-intensity long-lasting contractions, and fast-twitch glycolytic (type II) fibers …

Skeletal muscle toxicity is a rare and uncommon side effect of local anesthetic drugs.
Intramuscular injections of these agents regularly result in reversible myonecrosis. The …

BACKGROUND: In addition to inhibiting the excitation conduction process in peripheral
nerves, local anesthetics (LAs) cause toxic effects on the central nervous system …

Background: Several mechanisms have been proposed to explain toxicity of local
anesthetics to chondrocytes, including the blockade of potassium channels and …

Parabens are widely used as preservatives in many foods, cosmetics, toiletries, and
pharmaceuticals due to their relatively low toxicity profile and to a long history of safe use …