▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

Over a half a century of research has confirmed that neurotrophic factors promote the
survival and process outgrowth of isolated neurons in vitro. The mechanisms by which …

Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …

Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as
cell differentiation and survival, growth cessation and apoptosis of neurons. These events …

Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and
p75, which have been proposed to create a" high-affinity" NGF binding site through …

Neurotrophins are critical for the development and maintenance of the peripheral and
central nervous system. These highly homologous, homodimeric growth factors control cell …

Ligand-induced receptor oligomerization is an established mechanism for receptor-tyrosine
kinase activation. However, numerous receptor-tyrosine kinases are expressed in …

Neurotrophins were christened in consideration of their actions on the nervous system and,
for a long time, they were the exclusive interest of neuroscientists. However, more recently …

There is growing evidence that reduced neurotrophic support is a significant factor in the
pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's …