Urticaria

P Kolkhir, AM Giménez-Arnau, K Kulthanan… - Nature Reviews …, 2022 - nature.com
Urticaria is an inflammatory skin disorder that affects up to 20% of the world population at
some point during their life. It presents with wheals, angioedema or both due to activation …

The global burden of chronic urticaria for the patient and society

M Gonçalo, A Gimenéz‐Arnau… - British Journal of …, 2021 - academic.oup.com
Chronic urticaria (CU) affects about 1% of the world population of all ages, mostly young and
middle‐aged women. It usually lasts for several years (> 1 year in 25–75% of patients) and …

Chronic spontaneous urticaria: focus on pathophysiology to unlock treatment advances

A Kaplan, M Lebwohl, AM Giménez‐Arnau, M Hide… - Allergy, 2023 - Wiley Online Library
Chronic spontaneous urticaria (CSU) is a debilitating skin disease characterized by
intensely itchy wheals, angioedema, or both. Symptoms recur spontaneously, on a near …

[HTML][HTML] Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneous urticaria

M Maurer, W Berger, A Giménez-Arnau… - Journal of Allergy and …, 2022 - Elsevier
Background Chronic spontaneous urticaria (CSU) is inadequately controlled in many
patients and greatly affects quality of life. Remibrutinib, a highly selective, oral, novel …

The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells

AM Giménez-Arnau, L de Montjoye, R Asero… - The Journal of Allergy …, 2021 - Elsevier
Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular
infiltrate around small venules of the skin. It consists primarily of CD4 (+) lymphocytes, a …

[HTML][HTML] Urticaria: collegium internationale allergologicum (CIA) update 2020

M Maurer, K Eyerich, S Eyerich, M Ferrer… - International archives of …, 2020 - karger.com
This update on chronic urticaria (CU) focuses on the prevalence and pathogenesis of
chronic spontaneous urticaria (CSU), the expanding spectrum of patient-reported outcome …

Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies

EA Jacobsen, DJ Jackson, E Heffler… - Annual review of …, 2021 - annualreviews.org
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …

Predictors of treatment response in chronic spontaneous urticaria

JS Fok, P Kolkhir, MK Church, M Maurer - Allergy, 2021 - Wiley Online Library
The current therapeutic algorithm for chronic spontaneous urticaria (CSU), endorsed by the
international guideline, entails treatment escalation from second‐generation H1 …

Biologics for the use in chronic spontaneous urticaria: when and which

M Maurer, DA Khan, DEA Komi, AP Kaplan - The Journal of Allergy and …, 2021 - Elsevier
Guidelines for the treatment of chronic spontaneous urticaria (CSU) recommend the use of
the IgE-targeted biologic omalizumab in patients with antihistamine-refractory disease. The …

The role of crosstalk of immune cells in pathogenesis of chronic spontaneous urticaria

B Zhou, J Li, R Liu, L Zhu, C Peng - Frontiers in immunology, 2022 - frontiersin.org
Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous
wheal development and/or angioedema for more than six weeks and at least twice a week …