The transition from normal to chronic pain is believed to involve alterations in several brain
areas that participate in the perception of pain. These plastic changes are then responsible …

Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …

Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …

Importance Chronic back pain (CBP) is a leading cause of disability, and treatment is often
ineffective. Approximately 85% of cases are primary CBP, for which peripheral etiology …

Despite its great promise, neuroimaging has yet to substantially impact clinical practice and
public health. However, a developing synergy between emerging analysis techniques and …

Chronic pain is not simply a temporal continuum of acute pain. Studies on functional
plasticity in neural circuits of pain have provided mechanistic insights and linked various …

Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in
isolation from co-occurring cognitive and emotional features in patients. In this study, we …

Despite their ubiquitous presence, placebos and placebo effects retain an ambiguous and
unsettling presence in biomedicine. Specifically focused on chronic pain, this review …

Chronic pain and mental health disorders are common in the general population, and
epidemiological studies suggest that a bidirectional relationship exists between these 2 …

The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …