Human pluripotent stem cells (hPSCs) are increasingly used for cell-based regenerative
therapies worldwide, with embryonic and induced pluripotent stem cells as potential …

Recent advances in induced pluripotent stem cell technologies and phenotypic screening
shape the future of bioactive small-molecule discovery. In this review we analyze the impact …

With approximately 1.4 million men annually diagnosed with prostate cancer (PCa)
worldwide, PCa remains a dreaded threat to life and source of devastating morbidity. In …

Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …

Background Adult skin fibroblasts represent the most common starting cell type used to
generate human induced pluripotent stem cells (F-hiPSC) for clinical studies. Yet, a foetal …

In this immunohistological study on the peripheral retina of 3-year-old beagle dogs, excised
retina specimens were immunostained with antibodies against nestin, Oct4, Nanog, Sox2 …

Parallelization in Python integrates Message Passing Interface via the mpi4py module.
Since mpi4py does not support parallelization of objects greater than bytes, we developed …

Background The development of somatic reprogramming, especially purely chemical
reprogramming, has significantly advanced biological research. And chemical-induced …

A l'échelle cellulaire, l'intégration des signaux endogènes et exogènes et la réponse
adaptée qui en découle permettent aux cellules de prendre les décisions nécessaires aux …

Recent research demonstrated that reprogrammed human somatic cells can undergo self-
organised development, recapitulate milestones of embryonic development, and …