Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion

E Eggenhofer, V Benseler, A Kroemer… - Frontiers in …, 2012 - frontiersin.org
Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of
disorders. Although animal models show long term regenerative and immunomodulatory …

Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications

ME Castro-Manrreza… - Journal of immunology …, 2015 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiation into
mesenchymal lineages and that can be isolated from various tissues and easily cultivated in …

Mesenchymal stem cells deliver exogenous microRNA-let7c via exosomes to attenuate renal fibrosis

B Wang, K Yao, BM Huuskes, HH Shen, J Zhuang… - Molecular therapy, 2016 - cell.com
The advancement of microRNA (miRNA) therapies has been hampered by difficulties in
delivering miRNA to the injured kidney in a robust and sustainable manner. Using …

Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells

P Luz-Crawford, M Kurte, J Bravo-Alegría… - Stem cell research & …, 2013 - Springer
Abstract Introduction Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with
immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit …

Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices

RR Sharma, K Pollock, A Hubel, D McKenna - Transfusion, 2014 - Wiley Online Library
Mesenchymal stem cells (MSC s) have recently generated great interest in the fields of
regenerative medicine and immunotherapy due to their unique biologic properties. In this …

Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal …

LT Wang, KJ Liu, HK Sytwu, ML Yen… - Stem cells translational …, 2021 - academic.oup.com
Mesenchymal stem cell therapy (MSCT) for immune and inflammatory diseases continues to
be popular based on progressive accumulation of preclinical mechanistic evidence. This …

[HTML][HTML] Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway

B Zhang, RWY Yeo, RC Lai, EWK Sim, KC Chin… - Cytotherapy, 2018 - Elsevier
Background aims The immunomodulatory property of mesenchymal stromal cell (MSC)
exosomes is well documented. On the basis of our previous report that MSC exosomes …

Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study

MEJ Reinders, JW de Fijter, H Roelofs… - Stem cells …, 2013 - academic.oup.com
Despite excellent short-term results, long-term survival of transplanted kidneys has not
improved accordingly. Although alloimmune responses and calcineurin inhibitor-related …