Background Function and expression Arylamine N-acetyltransferases (NATs) are
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been …

Introduction Management of concomitant use of ART and TB drugs is difficult because of the
many drug–drug interactions (DDIs) between the medications. This systematic review …

The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient
drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce …

There are limited pharmacokinetic data for use of the first-line antituberculosis drugs during
infancy (< 12 months of age), when drug disposition may differ. Intensive pharmacokinetic …

The limit for possible survival after extremely preterm birth has steadily improved and
consequently, more premature neonates with increasingly lower gestational age at birth now …

Purpose This systematic review and meta-analysis assesses the pharmacokinetic (PK)
summary estimates of isoniazid (INH) between healthy volunteers and patients with …

Tuberculosis (TB) in young infants (< 3 months of age), often referred to as perinatal TB, is
underdiagnosed, leading to severe morbidity and high mortality. Perinatal TB includes both …

Background The available pharmacokinetic data on anti-tubercular drugs in children raises
the concern of suboptimal plasma concentrations attained when doses extrapolated from …

Aktuelle epidemiologische Daten zeigen in den letzten Jahren einen Anstieg der
Tuberkulose im Kindes-und Jugendalter. Es findet sich zudem auch in Deutschland ein …

Traditionally children have been treated for tuberculosis (TB) based on data extrapolated
from adults. However, we know that children present unique challenges that deserve special …